Chapter 18. The Role of Octamer Factors and Their Coactivators in the Lymphoid System
- Katya Ravid3,
- Jonathan D. Licht4
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch18
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Bertolino, E., Tiedt, R., Matthias, P. and Singh, H. (2002) The Role of Octamer Factors and Their Coactivators in the Lymphoid System, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch18
Editor Information
- 3
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 4
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- octamer (OCT) transcription factors;
- coactivators;
- lymphoid system;
- B-cell primary development;
- antigen-dependent B-cell development;
- T cells
Summary
The question arises as to which family member controls transcription of given target genes in vivo. Octamer transcription factors and their cognate-binding sites in control regions of lymphoid-specific genes constitute a paradigm for addressing the above question. A variety of molecular genetic and biochemical approaches have been employed in the study of this system and have led to new insights into the development and functioning of the lymphoid system.