Chapter 2. Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2
- Katya Ravid2,
- Jonathan D. Licht3
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch2
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Kim, S.-W. and Shivdasani, R. A. (2002) Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch2
Editor Information
- 2
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 3
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- megakaryocyte differentiation;
- erythroid differentiation;
- NF-E2 protein complex;
- gene expression;
- platelet biogenesis
Summary
Studies in cultured erythroid cells and transgenic mice have implicated NF-E2 in regulating globin gene expression, and targeted gene disruption has established the requirement for NF-E2 in terminal aspects of megakaryocyte differentiation and thrombocytopoiesis. The authors provide a synopsis of in vitro and in vivo studies pertaining to the composition and functions of NF-E2 in hematopoiesis.