Chapter 21. The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. P. Paul Liu,
  2. Lucio H. Castilla,
  3. Neeraj Adya

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch21

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Liu, P. P., Castilla, L. H. and Adya, N. (2002) The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch21

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. NIH, NHGRI, Building 49, Room 3A18, 49 Convent Drive, Bethesda, MD 20892

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • CBFβ;
  • smooth muscle myosin heavy chain (SMMHC);
  • inv(16) fusion gene CBFB-MYH11;
  • acute myeloid leukemias (AML);
  • leukemogenic function;
  • transgenic mouse models;
  • knock-in mouse model

Summary

All the in vitro and animal studies reported so far have used the type A CBFB-MY11 fusion gene, the most common fusion generated by combining CBFB exons 1–5 with MYH11 exons after intron A (encoding 165aa of CBFb and 446aa of SMMHC). This chapter reviews recent studies on CBFB-MYH11 that have led to a better understanding of how it contributes to the multistep progression of leukemia.

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