Chapter 22. EVI1 Rearrangements in Malignant Hematopoiesis

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Giuseppina Nucifora

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch22

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Nucifora, G. (2002) EVI1 Rearrangements in Malignant Hematopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch22

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Loyola University Medical Center, Cardinal Bernardin Cancer Center, Building 112, 2160 First Avenue, Maywood, IL 60153

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • EV11 rearrangements;
  • malignant hematopoiesis;
  • EV11 structure;
  • EV11 expression;
  • EV11 function;
  • myeloid leukemias;
  • MDS1/EV11;
  • transcription activity;
  • hematopietic differentiation;
  • cell growth

Summary

Chromosome band 3q26 contains the locus of two genes, MDS1/EV11 (myelodysplastic syndrome 1, ecoptropic viral integration 1) and EV11, encoding nuclear factors with two sets of DNA-binding zinc fingers. In this chapter, the current information on the two genes and their involvement in hematopoiesis and myeloid leukemia is reviewed.

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