Chapter 23. t(8;21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Richard C. Frank,
  2. Stephen D. Nimer

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch23

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Frank, R. C. and Nimer, S. D. (2002) t(8;21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch23

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Memorial Sloan-Kettering Cancer Center, Division of Hematologic Oncology, 1275 York Avenue, New York, NY 10021

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • t(8;21) AML;
  • Runt family;
  • transcription factors;
  • ETO gene;
  • AML1/ETO;
  • leukemogenesis;
  • gain-of-function properties

Summary

This review details the current understanding of the function of the 8;21 translocation protein, AML1/ETO, the first characterized and most frequently encountered AML1-fusion protein.

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