Chapter 25. MLL in Normal and Malignant Hematopoiesis

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Paul M. Ayton,
  2. Michael L. Cleary

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch25

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Ayton, P. M. and Cleary, M. L. (2002) MLL in Normal and Malignant Hematopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch25

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Stanford University Medical Center, Department of Pathology, Room L235, Stanford, CA 94305

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • mixed lineage leukemia (MLL);
  • domain structure;
  • Drosophila trx;
  • ALL-1 related (ALR) protein;
  • mammalian development;
  • mutations;
  • acute leukemias;
  • fusion proteins;
  • hematopoietic progenitors;
  • partner protein function;
  • MLL fusion protein-mediated leukemogenesis

Summary

Alterations of the mixed lineage leukemia (MLL) gene (also termed ALL-1 or HRX) located at chromosome band 11q23, define a distinct group of acute leukemias with unique clinical and biological features. This review focuses exclusively on aspects of normal MLL function during development, its disruption by various types of leukemogenic mutations, and how these data can be utilized to formulate models of MLL-mediated leukemogenesis.

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