Chapter 27. The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis
- Katya Ravid2,
- Jonathan D. Licht3
Published Online: 19 MAR 2002
DOI: 10.1002/0471223883.ch27
Copyright © 2001 by Wiley-Liss, Inc.
Book Title
Transcription Factors: Normal and Malignant Development of Blood Cells
Additional Information
How to Cite
Yamada, Y. and Rabbitts, T. H. (2002) The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch27
Editor Information
- 2
Department of Biochemistry, Boston University School of Medicine, Boston, MA
- 3
Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY
Publication History
- Published Online: 19 MAR 2002
- Published Print: 15 DEC 2000
ISBN Information
Print ISBN: 9780471350545
Online ISBN: 9780471223887
- Summary
- Chapter
Keywords:
- Lmo2 master gene;
- chromosomal translocations;
- transcription regulator;
- developmental regulation;
- cell fate;
- Lmo2 protein;
- T-cell acute leukemia;
- hematopiesis
Summary
The LMO2 gene typifies the type of gene associated with chromosomal translocation breakpoints in acute leukemia. This gene encodes a protein that displays features of a transcriptional regulator, a developmental regulator and a master gene regulator, as proposed previously for chromosomal translocation genes in acute tumors. In this chapter the authors summarize data illustrating these points, which show the normal role of Lmo2 in hematopoiesis and vascular formation and the aberrant role in the development of T cells prior to tumor formation.