Chapter 28. The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Gerd A. Blobel

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch28

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Blobel, G. A. (2002) The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch28

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Children's Hospital of Philadelphia, Research Hematology, Abramson Research Center 316, 34th & Civic Center Boulevard, Philadelphia, PA 19104

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • CBP/p300;
  • hematopoiesis;
  • leukemia-associated chromosomal translocations

Summary

This chapter focuses on the role of CBP/p300 in the transcriptional control of hematopoietic cell differentiation. Following an initial general overview of CBP/p300, the hematopoietic transcription factors regulated by CPB/p300 are described in a systematic fashion. Leukemia-associated chromosomal translocations involving the CBP/p300 genes are discussed briefly, and the mechanistic aspects of CBP/p300 function are presented.

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