Chapter 29. The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Marcello Arsura,
  2. Gail E. Sonenshein

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch29

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Arsura, M. and Sonenshein, G. E. (2002) The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch29

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Boston University School of Medicine, 715 Albany Street, Boston, MA 02118

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • c-myc oncogene;
  • c-myb oncogene;
  • hematopoiesis;
  • leukemogenesis

Summary

In the past 20 years, the study of the v-myb and v-myc viral oncogenes has greatly increased our understanding of the molecular mechanisms leading to neoplastic transformation of hematopoietic cells. This review dissects the roles of c-myb and c-myc genes in the regulation of hematopoiesis and leukemogenesis.

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