Chapter 3. Transcription Factors Involved in Lineage-specific Gene Expression During Megakaryopoiesis

  1. Katya Ravid3,
  2. Jonathan D. Licht4
  1. Yulia Kaluzhny1,
  2. Katya Ravid3,
  3. Mortimer Poncz2

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch3

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Kaluzhny, Y., Ravid, K. and Poncz, M. (2002) Transcription Factors Involved in Lineage-specific Gene Expression During Megakaryopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch3

Editor Information

  1. 3

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 4

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. 1

    Boston University School of Medicine, Department of Biochemistry, Whitaker Cardiovascular Institute, 115 Albany Street, Boston, MA 02118

  2. 2

    Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104

  3. 3

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

SEARCH

CHAPTER TOOLS

Get PDF (330K)

Keywords:

  • transcription factors;
  • gene expression;
  • megakaryocytes;
  • ectopic expression;
  • transgenic mice;
  • gene targeting

Summary

The discovery and cloning of thrombopoietin (TPO), the ligand of the myeloproliferative (Mpl) receptor, opened a new perspective in megakaryocyte differentiation studies. This chapter focuses on reviewing studies related to the role of specific transcription factors in promoting gene expression in the megakaryocytic lineage. Some of these factors may mediate the effects of TPO on this lineage.

Get PDF (330K)