Chapter 4. Role of the TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Stephen J. Brandt

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch4

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Brandt, S. J. (2002) Role of the TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch4

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Vanderbilt University Medical Center, Division of Hematology-Oncology, Room 547 MRB II, Nashville, TN 37232

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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CHAPTER TOOLS

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Keywords:

  • TAL1/SCL transcription factor;
  • hematopoiesis;
  • leukemia;
  • TAL1 protein products;
  • TAL1 gene expression;
  • DNA-binding preferences;
  • target genes

Summary

Since its initial discovery at the site of a recurrent chromosomal translocation, efforts by international laboratories have demonstrated the oncogenic consequences of ectopic TAL1 expression and the importance of this transcription factor for normal hematopoiesis. In addition to its actions in leukemogenesis, TAL1 is required for the specification of hematopoietic fate and possibly vascular patterning in embryogenesis.

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