Chapter 5. EKLF and the Development of the Erythroid Lineage

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. James J. Bieker

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch5

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

How to Cite

Bieker, J. J. (2002) EKLF and the Development of the Erythroid Lineage, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch5

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Mount Sinai School of Medicine, Department of Biochemistry and Molecular Biology, One Gustave Lower Levy Place, New York, NY 10029

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • erythroid Krüppel-like factor (EKLF);
  • erythroid expression;
  • transcriptional activation;
  • regulation

Summary

This chapter focuses on the transcriptional activator known as erythroid Krüppel-like factor (EKLF). EKLF was originally isolated via a differential screening approach whereby mRNA that was specifically expressed in erythroid cells was identified after subtraction with common messages expressed in a myeloid cell line.