Chapter 6. RUNX1(AML1) and CBFB: Genes Required for the Development of all Definitive Hematopoietic Lineages

  1. Katya Ravid3,
  2. Jonathan D. Licht4
  1. Nancy A. Speck1,
  2. Elaine Dzierzak2

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch6

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Speck, N. A. and Dzierzak, E. (2002) RUNX1(AML1) and CBFB: Genes Required for the Development of all Definitive Hematopoietic Lineages, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch6

Editor Information

  1. 3

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 4

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. 1

    Dartmouth Medical School, Department of Biochemistry, 7200 Vail Building, Room 315, Hanover, NH 03755

  2. 2

    Department of Cell Biology and Genetics, Erasmus University, The Netherlands

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • Runx1;
  • Cbfb;
  • definitive hematopoietic cells;
  • hematopoietic lineages;
  • gene dosage effects;
  • RUNX1;
  • CBFB

Summary

The core-binding factors (CBFs) , which are also known as the polyomavirus enhancer binding protein 2 (PEBP2) , constitute a small family of transcription factors that participate in multiple developmental processes in flies and mammals. The functional consequences of CBF mutations are described in more detail in other chapters in this book. This chapter focuses on RUNX1 and CBFB function in normal hematopoiesis.

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