Chapter 7. PU.1 and the Development of the Myeloid Lineage

  1. Katya Ravid2,
  2. Jonathan D. Licht3
  1. Daniel G. Tenen

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch7

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Tenen, D. G. (2002) PU.1 and the Development of the Myeloid Lineage, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch7

Editor Information

  1. 2

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 3

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, MA 02115

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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CHAPTER TOOLS

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Keywords:

  • stem cell;
  • myeloid lineage;
  • PU.1 protein-protein interactions;
  • lineage-specific coactivators;
  • c-Jun;
  • Ras;
  • myeloid;
  • growth factor receptors;
  • target genes;
  • rescue assays

Summary

This chapter focuses on myeloid lineage commitment and differentiation. In addition, recent studies have emphasized several themes in terms of myeloid differentiation. These include mechanisms of downregulation of alternative pathways, as well as the increasingly important role of transcription factor interactions in lineage commitment decisions. Examples of these two mechanisms are highlighted, as regulation of PU.1 function is likely to be mediated through these mechanisms.

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