Chapter 9. Homeobox Gene Networks and the Regulation of Hematopoiesis

  1. Katya Ravid4,
  2. Jonathan D. Licht5
  1. Guy Sauvageau1,
  2. R. Keith Humphries2,
  3. H. Jeffrey Lawrence3,
  4. Corey Largman3

Published Online: 19 MAR 2002

DOI: 10.1002/0471223883.ch9

Book Title

Transcription Factors: Normal and Malignant Development of Blood Cells

Transcription Factors: Normal and Malignant Development of Blood Cells

Additional Information

How to Cite

Sauvageau, G., Humphries, R. K., Lawrence, H. J. and Largman, C. (2002) Homeobox Gene Networks and the Regulation of Hematopoiesis, in Transcription Factors: Normal and Malignant Development of Blood Cells (eds K. Ravid and J. D. Licht), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223883.ch9

Editor Information

  1. 4

    Department of Biochemistry, Boston University School of Medicine, Boston, MA

  2. 5

    Derald H. Ruttenberg Cancer Center and Department of Medicine, Mount Sinai School of Medicine, New York, NY

Author Information

  1. 1

    Institute de Researches, Cliniques de Montreal, 110 Pine Avenue West, Montreal (Quebec) H2W 1R7, Canada

  2. 2

    Department of Medicine, University of British Columbia, Canada

  3. 3

    Department of Medicine, University of California, California

Publication History

  1. Published Online: 19 MAR 2002
  2. Published Print: 15 DEC 2000

ISBN Information

Print ISBN: 9780471350545

Online ISBN: 9780471223887

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Keywords:

  • homeobox gene networks;
  • hematopoiesis;
  • Hox genes;
  • regulation;
  • leukemia

Summary

Homeobox genes, and Hox genes in particular, are expressed in complex stage and potentially lineage-specific patterns in normal hematopoietic cells. Perturbation of Hox gene expression yields a wide array of hematopoietic abnormalities.

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