Chapter 1. Stem Cell Systems: Basic Principles and Methodologies

  1. Peter J. Quesenberry2,
  2. Gary S. Stein2,
  3. Bernard G. Forget3,
  4. Sherman M. Weissman3
  1. Susan K. Nilsson1,
  2. Peter J. Quesenberry2

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch1

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Nilsson, S. K. and Quesenberry, P. J. (2002) Stem Cell Systems: Basic Principles and Methodologies, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch1

Editor Information

  1. 2

    University of Massachusetts, Worcester, Massachusetts

  2. 3

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. 1

    Peter MacCullum Cancer Institute, A' Beckett St., Melbourne 3000, Australia

  2. 2

    University of Massachusetts, Worcester, Massachusetts

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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CHAPTER TOOLS

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Keywords:

  • stem cells;
  • hematopoiesis;
  • in vitro clonal progenitor assays;
  • stromal-based assays;
  • in vitro stromal-based culture systems;
  • cytokines;
  • in vivo engraftment assay;
  • hematopoietic stem cell systems

Summary

This introductory chapter centers upon the extensive information has that been developed on both human and murine stem cell systems and their cytokine and stromal regulators. The authors demonstrate how researchers continue to expand their insights into this system with a growing potential for application to gene therapy or to marrow stem cell expansion.

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