Chapter 10. Delivery Systems for Gene Therapy: Adeno-Associated Virus 2

  1. Peter J. Quesenberry2,
  2. Gary S. Stein2,
  3. Bernard G. Forget3,
  4. Sherman M. Weissman3
  1. Arun Srivastava

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch10

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Srivastava, A. (2002) Delivery Systems for Gene Therapy: Adeno-Associated Virus 2, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch10

Editor Information

  1. 2

    University of Massachusetts, Worcester, Massachusetts

  2. 3

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. Division of Hematology/Oncology, Departments of Medicine, Microbiology & Immunology, Medical Science Building 255, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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Keywords:

  • gene therapy;
  • delivery systems;
  • adeno-associated virus 2 (AAV);
  • life cycle;
  • recombinant AAV vectors;
  • AAV-mediated transduction;
  • gene expression

Summary

This chapter attempts to highlight the salient features of AAV in general and outline a number of advantages of AAV vectors for their potential use in human gene therapy.

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