Chapter 17. Clinical Applications of Gene Therapy in Cancer: Modification of Sensitivity to Therapeutic Agents

  1. Peter J. Quesenberry4,
  2. Gary S. Stein4,
  3. Bernard G. Forget5,
  4. Sherman M. Weissman5
  1. Thomas Licht1,2,
  2. Michael M. Gottesman3,
  3. Ira Pastan1

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch17

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Licht, T., Gottesman, M. M. and Pastan, I. (2002) Clinical Applications of Gene Therapy in Cancer: Modification of Sensitivity to Therapeutic Agents, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch17

Editor Information

  1. 4

    University of Massachusetts, Worcester, Massachusetts

  2. 5

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. 1

    Laboratory of Molecular Biology, National Cancer Institute, NIH, Building 37, Room 416, 37 Convent Drive, Bethesda, MD 20892–4255

  2. 2

    University of Ulm, Department of Internal Medicine III, Robert-Kock-Strasse 8, D-89081 Ulm, Germany

  3. 3

    Laboratory of Cell Biology, National Cancer Institute, NIH, Building 37, Room lB22, 37 Convent Drive, Bethesda, MD 20892-4255

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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Keywords:

  • cancer;
  • gene therapy;
  • clinical applications;
  • anticancer drugs;
  • chemoresistance;
  • proteins;
  • drug resistance genes;
  • interference;
  • hematopoietic cells

Summary

An increasing number of mechanisms that render cells chemoresistant are being uncovered. The authors of this chapter focus on mechanisms of drug resistance that can potentially be overcome. Strategies to modify chemoresistance are aimed at either interfering with transcription or translation of the respective genes or at modulating the function of their products.

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