Chapter 18. Clinical Applications of Gene Therapy: Brain Tumors

  1. Peter J. Quesenberry3,
  2. Gary S. Stein3,
  3. Bernard G. Forget4,
  4. Sherman M. Weissman4
  1. Kenneth W. Culver1,
  2. John C. van Gilder2

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch18

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Culver, K. W. and van Gilder, J. C. (2002) Clinical Applications of Gene Therapy: Brain Tumors, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch18

Editor Information

  1. 3

    University of Massachusetts, Worcester, Massachusetts

  2. 4

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. 1

    Director, Gene Therapy Research and Clinical Affairs, Codon Pharmaceuticals, Gaithesburg, MD 20877

  2. 2

    Chairman of the Division of Neurosurgery, University of Iowa School of Medicine, Iowa City, IA 52242

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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Keywords:

  • brain tumors;
  • gene therapy;
  • clinical applications;
  • HSV-TK gene

Summary

Despite the many advances in medicine over the past decade, radiotherapy and adjuvant chemotherapy have minimally improved the prognosis for most patients with glioblastoma multiforme (GBM) and symptomatic CNS metastases. Gene transfer has a number of novel new approaches to the selective elimination of tumor cells that may be beneficial for the treatment of brain tumors. These applications are the subject of this chapter.

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