Chapter 2. Cytokine/Growth Factor Responsiveness of Early Hemopoietic Progenitor Cells
- Peter J. Quesenberry2,
- Gary S. Stein2,
- Bernard G. Forget3,
- Sherman M. Weissman3
Published Online: 13 MAY 2002
DOI: 10.1002/0471223956.ch2
Copyright © 1998 by Wiley-Liss, Inc.
Book Title
Stem Cell Biology and Gene Therapy
Additional Information
How to Cite
Burgess, A. W. (2002) Cytokine/Growth Factor Responsiveness of Early Hemopoietic Progenitor Cells, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch2
Editor Information
- 2
University of Massachusetts, Worcester, Massachusetts
- 3
Yale University School of Medicine, New Haven, Connecticut
Publication History
- Published Online: 13 MAY 2002
- Published Print: 27 AUG 1998
ISBN Information
Print ISBN: 9780471146568
Online ISBN: 9780471223955
- Summary
- Chapter
Keywords:
- early hemopoietic progenitor cells;
- cytokine responsiveness;
- stromal cells;
- stem cells;
- expansion;
- stem cell mobilization;
- FLT-3/FLK-2 ligand;
- stem cell factor (SCF);
- granulocyte-colony stimulating factor;
- interleukin-3;
- thrombopoietin;
- autocrine stimulation;
- myeloid leukemias
Summary
This chapter focuses on a description and analysis of the cytokines that regulate the early hemopoietic progenitor cells. There is a brief description of “different” classes of early hemopoietic progenitor/stem cells and a discussion of the assays that might be used to predict the effectiveness of genetic manipulation strategies. The role of cytokine/growth factor networks for the regulation of self-renewal, proliferation, lineage commitment, differentiation, and function is also presented. Finally, the interactions between stromal/endothelial cells, the extracellular matrix systems, and the growth factor/cytokine networks have now been explored in detail, and some of the recent results of these studies are discussed.