Chapter 3. Molecular Mechanisms Controlling the Cell Cycle and Proliferation-Differentiation Interrelationships
- Peter J. Quesenberry4,
- Gary S. Stein4,
- Bernard G. Forget5,
- Sherman M. Weissman5
Published Online: 13 MAY 2002
DOI: 10.1002/0471223956.ch3
Copyright © 1998 by Wiley-Liss, Inc.
Book Title
Stem Cell Biology and Gene Therapy
Additional Information
How to Cite
Stein, G. S., van Wijnen, A. J., Hushka, D. R., Frenkel, B., Lian, J. B. and Stein, J. L. (2002) Molecular Mechanisms Controlling the Cell Cycle and Proliferation-Differentiation Interrelationships, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch3
Editor Information
- 4
University of Massachusetts, Worcester, Massachusetts
- 5
Yale University School of Medicine, New Haven, Connecticut
Publication History
- Published Online: 13 MAY 2002
- Published Print: 27 AUG 1998
ISBN Information
Print ISBN: 9780471146568
Online ISBN: 9780471223955
- Summary
- Chapter
Keywords:
- growth regulatory mechanisms;
- proliferation;
- cell cycle progression;
- regulated mechanisms;
- transcriptional control;
- cell cycle regulatory factors
Summary
In this chapter, the authors explore the broad spectrum of signaling mechanisms that integrate and amplify growth-related regulatory cues that modulate the expression of genes requisite for proliferation and cell cycle control. The modularly organized promoter elements of genes that support the onset and progression of proliferation are presented as blueprints for growth control within the context of responsiveness to mediators of proliferative status. These encompass cytokines, growth factors, steroid hormones, and cell cycle regulatory factors that include but are not restricted to cyclins, cyclin-dependent kinases, cyclin inhibitors, and tumor suppressor proteins. Additionally, the authors address the activities of factors that mediate the postproliferative downregulation of cell cycle and cell growth regulatory pathways to support quiescence and expression of phenotypic genes at the onset of differentiation.