Chapter 6. Delivery Systems for Gene Therapy: The Adenovirus

  1. Peter J. Quesenberry2,
  2. Gary S. Stein2,
  3. Bernard G. Forget3,
  4. Sherman M. Weissman3
  1. Thomas Shenk

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch6

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Shenk, T. (2002) Delivery Systems for Gene Therapy: The Adenovirus, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch6

Editor Information

  1. 2

    University of Massachusetts, Worcester, Massachusetts

  2. 3

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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Keywords:

  • adenovirus;
  • gene therapy;
  • delivery stems;
  • vectors

Summary

Adenovirus-based vectors for the delivery of therapeutic genes are now under development. The group C viruses, adenovirus type 2 and type 5 (Ad2 and Ad5), are the most intensively studied serotypes at the molecular level, and vector applications have focused almost exclusively on them. The closely related Ad2 and Ad5 are attractive vector candidates. Adenoviruses and adenovirus vectors can be propagated relatively easily to produce high-titer stocks. Adenoviruses will express their genes in cells that are not actively growing and dividing, suggesting that they might be especially useful for in vivo vector applications where the majority of target cells will not be growing. Adenovirus-based vectors are the subject of this chapter.

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