Chapter 7. Gene Transfer to Muscle and Spinal Cord Using Herpes Simplex Virus-Based Vectors

  1. Peter J. Quesenberry3,
  2. Gary S. Stein3,
  3. Bernard G. Forget4,
  4. Sherman M. Weissman4
  1. Johnny Huard1,
  2. William F. Goins2,
  3. Giridhar R. Akkaraju2,
  4. David Krisky2,
  5. Tom Oligino2,
  6. Peggy Marconi2,
  7. Charles S. Day1,
  8. Joseph C. Glorioso2

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch7

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Huard, J., Goins, W. F., Akkaraju, G. R., Krisky, D., Oligino, T., Marconi, P., Day, C. S. and Glorioso, J. C. (2002) Gene Transfer to Muscle and Spinal Cord Using Herpes Simplex Virus-Based Vectors, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch7

Editor Information

  1. 3

    University of Massachusetts, Worcester, Massachusetts

  2. 4

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. 1

    Department of Orthopedic Surgery, Musculoskeletal Research Center, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

  2. 2

    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

SEARCH

CHAPTER TOOLS

Get PDF (3908K)

Keywords:

  • cell therapy;
  • gene therapy;
  • HSV-1;
  • gene delivery;
  • muscle;
  • HSV-1 vector;
  • impediments;
  • spinal cord neurons;
  • intramuscular inoculation

Summary

The recovery of injured muscle depends on several factors, such as muscle regeneration, revascularization, and reinnervation. Recovery can be improved with gene therapy procedures that deliver substances that promote the recovery of the injured muscle and may also prevent complications associated with muscle healing and contractures. Two different approaches have been employed to deliver genes to muscle: cell therapy based on myoblast transplantation (MT) and gene therapy (GT) using viral and nonviral vectors. These approaches are discussed in this chapter.

Get PDF (3908K)