Chapter 8. Herpes Virus Vectors

  1. Peter J. Quesenberry2,
  2. Gary S. Stein2,
  3. Bernard G. Forget3,
  4. Sherman M. Weissman3
  1. Xandra O. Breakefield,
  2. Peter Pechan,
  3. Karen Johnston,
  4. David Jacoby

Published Online: 13 MAY 2002

DOI: 10.1002/0471223956.ch8

Book Title

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy

Additional Information

How to Cite

Breakefield, X. O., Pechan, P., Johnston, K. and Jacoby, D. (2002) Herpes Virus Vectors, in Stem Cell Biology and Gene Therapy (eds P. J. Quesenberry, G. S. Stein, B. G. Forget and S. M. Weissman), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471223956.ch8

Editor Information

  1. 2

    University of Massachusetts, Worcester, Massachusetts

  2. 3

    Yale University School of Medicine, New Haven, Connecticut

Author Information

  1. Massachusetts General Hospital East, Molecular Neurogenetics Unit, 13th Street, Building 149, Charlestown, MA 02129

Publication History

  1. Published Online: 13 MAY 2002
  2. Published Print: 27 AUG 1998

ISBN Information

Print ISBN: 9780471146568

Online ISBN: 9780471223955

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Keywords:

  • herpes simplex virus;
  • life cycle;
  • recombinant virus vectors;
  • amplicon vectors

Summary

Virus-derived vectors provide an efficient means of gene delivery into dividing and nondividing cells in culture and in vivo. Vectors derived from herpes simplex virus type 1 (HSV-1) have some particular advantages as compared with other vectors. HSV-1 is a large (152 kb) double-stranded DNA virus with a broad tropism (Roizman and Sears, 1996). It is a pathogen in humans causing skin lesions during productive infection and able to assume a latent state in sensory neurons for very long periods (years). This chapter focuses on HSV vectors.

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