Statistical Analysis of Protein Folding Kinetics
- Richard A. Friesner
Published Online: 13 MAR 2002
DOI: 10.1002/0471224421.ch1
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Computational Methods for Protein Folding, Volume 120
Additional Information
How to Cite
Dinner, A. R., So, S.-S. and Karplus, M. (2002) Statistical Analysis of Protein Folding Kinetics, in Computational Methods for Protein Folding, Volume 120 (ed R. A. Friesner), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471224421.ch1
Editor Information
Columbia University, New York, New York, USA
Publication History
- Published Online: 13 MAR 2002
- Published Print: 4 JAN 2002
Book Series:
Book Series Editors:
- I. Prigogine7,8,
- Stuart A. Rice9
Series Editor Information
- 7
Center for Studies in Statistical Mechanics and Complex Systems, The University of Texas, Austin, Texas, USA
- 8
International Solvay Institutes, Université Libre de Bruxelles, Brussels, Belgium
- 9
Department of Chemistry and The James Franck Institute, The University of Chicago, Chicago, Illinois, USA
ISBN Information
Print ISBN: 9780471209553
Online ISBN: 9780471224426
- Summary
- Chapter
Keywords:
- proteins;
- statistical methods;
- lattice models;
- folding rates;
- unfolding rates;
- homologous proteins
Summary
In recent years, an increasing number of proteins that lack significantly populated folding intermediates and thus exhibit two-state folding kinetics have been identified, and a range of data have been tabulated for them. The initial linear analyses of such proteins indicated that their folding rates are determined primarily by their native structures. More recently, a nonlinear, multiple-descriptor approach revealed that there is a significant dependence on the stability as well. These and related studies are discussed in Section IV.A, after an overview of the statistical methods employed in this area (Section II) and a review of the results from lattice models (Section III). An in-depth analysis of a database of 33 proteins that fold with two- or weakly three-state kinetics is presented in Sections IV.B through V. The relation of the statistical results to experiments and the model studies is discussed in Sections VI and VII.