A Unified Approach to the Prediction of Protein Structure and Function
- Richard A. Friesner
Published Online: 13 MAR 2002
DOI: 10.1002/0471224421.ch4
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Computational Methods for Protein Folding, Volume 120
Additional Information
How to Cite
Skolnick, J. and Kolinski, A. (2002) A Unified Approach to the Prediction of Protein Structure and Function, in Computational Methods for Protein Folding, Volume 120 (ed R. A. Friesner), John Wiley & Sons, Inc., New York, USA. doi: 10.1002/0471224421.ch4
Editor Information
Columbia University, New York, New York, USA
Publication History
- Published Online: 13 MAR 2002
- Published Print: 4 JAN 2002
Book Series:
Book Series Editors:
- I. Prigogine4,5,
- Stuart A. Rice6
Series Editor Information
- 4
Center for Studies in Statistical Mechanics and Complex Systems, The University of Texas, Austin, Texas, USA
- 5
International Solvay Institutes, Université Libre de Bruxelles, Brussels, Belgium
- 6
Department of Chemistry and The James Franck Institute, The University of Chicago, Chicago, Illinois, USA
ISBN Information
Print ISBN: 9780471209553
Online ISBN: 9780471224426
- Summary
- Chapter
Keywords:
- protein structure;
- unified folding scheme;
- threading;
- comparative models;
- ab initio folding;
- reduced models;
- atomic models;
- biochemical function;
- low-resolution structures;
- ligand identification
Summary
The major focus of this review is to describe a unified approach to protein structure prediction that reduces to threading plus structure refinement when an example of the probe sequence is found; but if not, it incorporates information from weakly significant probe sequence-template structure matches and then does ab initio folding with the structural information gleaned from such matches. It has the advantage that it can predict a novel fold even though some of the information comes from threading on already solved structures.