Chapter 1. Alternative Strategies for Targeted Delivery of Nucleic Acid–Liposome Complexes
- David T. Curiel M.D. and
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Templeton, N. S. (2002) Alternative Strategies for Targeted Delivery of Nucleic Acid–Liposome Complexes, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch1
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- non-viral delivery;
- gene therapy;
- gene delivery;
- cell entry;
- bilamellar invaginated vesicles (BIV);
- systemic therapeutics;
Liposomes provide efficient delivery of therapeutic agents that can be repeatedly administered, are non-immunogenic, can penetrate beyond tight barriers to reach disease targets, and can be regulated as drugs versus biologics. Furthermore, using improved technologies, liposomes can be targeted for delivery to specific cell surface receptors resulting in efficient nuclear uptake of nucleic acids within the cell. Current methods have been inefficient in producing high levels of gene expression in target cells after delivery of plasmid DNA. This chapter focuses on the problems of the current targeting strategies and on new approaches that overcome the obstacles discussed.