Chapter 10. Receptor Targeting of Adeno-Associated Virus Vectors
- David T. Curiel M.D. and
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Büning, H., Ried, M. U. and Hallek, M. (2002) Receptor Targeting of Adeno-Associated Virus Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch10
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Adeno-Associated Virus;
- receptor targeting;
- cell specific vectors;
- capsid modification;
- ligand insertion;
- bispecific antibody
One of the most promising viral vectors is derived from the adeno-associated virus type 2 (AAV-2), a member of the parvovirus family. Since AAV-2 has a broad tissue tropism it is attractive for in vitro gene transfer into various tissues. However, the broad host range is a disadvantage for in vivo gene therapy, because a selective, tissue- or organ-restricted infection is desirable to enhance the safety and efficiency for the gene transfer in vivo. Therefore, increasing efforts are undertaken to retarget AAV-2 based vectors to specific receptors a summary of which is given in this review.