Chapter 11. Mechanisms of Retroviral Particle Maturation and Attachment
- David T. Curiel M.D. and
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Miyanohara, A. and Friedmann, T. (2003) Mechanisms of Retroviral Particle Maturation and Attachment, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch11
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- cell uptake;
An understanding of the mechanisms of virus attachment and uptake in mammalian cells is vital for developing targeted viral vectors for in vivo gene delivery. Retroviruses use several classes of sites and receptors for initial cell binding and uptake, including glycosaminoglycan and protein components of the cell surface. Full characterization of these sites and the viral ligands will aid in the eventual design of more efficient and targeted retrovirus and lentivirus vectors.