Chapter 11. Mechanisms of Retroviral Particle Maturation and Attachment

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. Atsushi Miyanohara Ph.D. and
  2. Theodore Friedmann M.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch11

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Miyanohara, A. and Friedmann, T. (2002) Mechanisms of Retroviral Particle Maturation and Attachment, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch11

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. Center for Molecular Genetics and Department of Pediatrics, UCSD School of Medicine, La Jolla, California, USA

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • retrovirus;
  • lentivirus;
  • assembly;
  • pseudotype;
  • VSV-G;
  • receptor;
  • attachment;
  • cell uptake;
  • targeting

Summary

An understanding of the mechanisms of virus attachment and uptake in mammalian cells is vital for developing targeted viral vectors for in vivo gene delivery. Retroviruses use several classes of sites and receptors for initial cell binding and uptake, including glycosaminoglycan and protein components of the cell surface. Full characterization of these sites and the viral ligands will aid in the eventual design of more efficient and targeted retrovirus and lentivirus vectors.