Chapter 12. Targeting Retroviral Vectors Using Molecular Bridges
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
DOI: 10.1002/0471234303.ch12
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Vector Targeting for Therapeutic Gene Delivery
Additional Information
How to Cite
Young, J. A. T. (2003) Targeting Retroviral Vectors Using Molecular Bridges, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch12
Editor Information
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
Publication History
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
ISBN Information
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Summary
- Chapter
Keywords:
- retrovirus;
- targeting;
- GATEs;
- bridges;
- ASLV;
- TVA;
- TVB
Summary
This chapter discusses the use of molecular bridges to direct infection by retroviral vectors to specific cell types. These bridges include crosslinked antibodies and ligands for specific cell surface receptors as well as GATEs (guided adaptors for virus entry) comprised of soluble retroviral receptors fused to specific ligands or to single chain antibodies.