Chapter 12. Targeting Retroviral Vectors Using Molecular Bridges

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. John A. T. Young Ph.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch12

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Young, J. A. T. (2003) Targeting Retroviral Vectors Using Molecular Bridges, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch12

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • retrovirus;
  • targeting;
  • GATEs;
  • bridges;
  • ASLV;
  • TVA;
  • TVB

Summary

This chapter discusses the use of molecular bridges to direct infection by retroviral vectors to specific cell types. These bridges include crosslinked antibodies and ligands for specific cell surface receptors as well as GATEs (guided adaptors for virus entry) comprised of soluble retroviral receptors fused to specific ligands or to single chain antibodies.