Chapter 19. Engineering Targeted Bacteriophage as Evolvable Vectors for Therapeutic Gene Delivery

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. David Larocca Ph.D. and
  2. Andrew Baird Ph.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch19

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Larocca, D. and Baird, A. (2003) Engineering Targeted Bacteriophage as Evolvable Vectors for Therapeutic Gene Delivery, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch19

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. Selective Genetics, Inc., San Diego, California, USA

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • targeted bacteriophage;
  • evolving vectors;
  • therapeutic gene delivery;
  • conferred tropism;
  • simplified targeting;
  • mechanism of phage gene delivery;
  • targeted phage gene therapy;
  • transgene expression;
  • directed evolution

Summary

A fundamental challenge for gene therapy is the development of gene delivery vectors that target genes to the appropriate cells in the body for maximal therapeutic effect while minimizing vector toxicity. In this chapter we review strategies for adapting phage vectors for targeted gene delivery using both rational design and directed evolution.