Chapter 2. Targeted Gene Delivery via Lipidic Vectors

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. Song Li M.D., Ph.D.,
  2. Zheng Ma M.D., Ph.D.,
  3. Yadi Tan Ph.D.,
  4. Feng Liu Ph.D.,
  5. John Dileo M.S. and
  6. Leaf Huang Ph.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch2

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Li, S., Ma, Z., Tan, Y., Liu, F., Dileo, J. and Huang, L. (2003) Targeted Gene Delivery via Lipidic Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch2

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • targeted gene delivery;
  • lipidic vectors;
  • drug delivery;
  • neutral liposomes;
  • anionic liposomes;
  • passive targeting;
  • self-assembled lipidic vectors;
  • LPD-I;
  • LPD-II

Summary

The success of gene therapy largely depends on the development of suitable vectors or vehicles that can deliver a gene(s) to specific target tissue with minimal toxicity. In this chapter, we focus on lipidic vectors for targeted gene delivery. Emphasis is placed on the understanding of in vivo barriers in targeted gene delivery via the vascular route.