Chapter 2. Targeted Gene Delivery via Lipidic Vectors
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
DOI: 10.1002/0471234303.ch2
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Vector Targeting for Therapeutic Gene Delivery
Additional Information
How to Cite
Li, S., Ma, Z., Tan, Y., Liu, F., Dileo, J. and Huang, L. (2003) Targeted Gene Delivery via Lipidic Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch2
Editor Information
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
Publication History
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
ISBN Information
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Summary
- Chapter
Keywords:
- targeted gene delivery;
- lipidic vectors;
- drug delivery;
- neutral liposomes;
- anionic liposomes;
- passive targeting;
- self-assembled lipidic vectors;
- LPD-I;
- LPD-II
Summary
The success of gene therapy largely depends on the development of suitable vectors or vehicles that can deliver a gene(s) to specific target tissue with minimal toxicity. In this chapter, we focus on lipidic vectors for targeted gene delivery. Emphasis is placed on the understanding of in vivo barriers in targeted gene delivery via the vascular route.