Chapter 2. Targeted Gene Delivery via Lipidic Vectors
- David T. Curiel M.D. and
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Li, S., Ma, Z., Tan, Y., Liu, F., Dileo, J. and Huang, L. (2002) Targeted Gene Delivery via Lipidic Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch2
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- targeted gene delivery;
- lipidic vectors;
- drug delivery;
- neutral liposomes;
- anionic liposomes;
- passive targeting;
- self-assembled lipidic vectors;
The success of gene therapy largely depends on the development of suitable vectors or vehicles that can deliver a gene(s) to specific target tissue with minimal toxicity. In this chapter, we focus on lipidic vectors for targeted gene delivery. Emphasis is placed on the understanding of in vivo barriers in targeted gene delivery via the vascular route.