Chapter 20. Targeting Bacteriophage Vectors
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
DOI: 10.1002/0471234303.ch20
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Vector Targeting for Therapeutic Gene Delivery
Additional Information
How to Cite
Saggio, I. (2003) Targeting Bacteriophage Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch20
Editor Information
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
Publication History
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
ISBN Information
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Summary
- Chapter
Keywords:
- phage;
- lambda;
- penton base;
- adenovirus;
- endocytosis;
- bacteriophage;
- integrin;
- targeting
Summary
Viruses represent the most efficient system to encapsidate, protect and deliver DNA into cells. This fact has stimulated their exploitment as gene transfer vectors for mammalian cells. Nevertheless, their physical complexity has frequently represented an obstacle for the production of targeted constructs. In addition, eukaryotic safety problems have been encountered when analyzing in vivo these virus-based preparations. In this chapter we will present innovative delivery systems, based on prokaryotic viruses, engineered to target eukaryotic receptors. These chimera should ensure several theoretical advantages: low costs, reduced toxicity, and high selectivity. The specific components of these chimera and their properties, analyzed in a gene transfer perspective, will be detailed in the different sections of the chapter.