Chapter 21. Tumor/Tissue-Selective Promoters

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. Mario Fernandez Ph.D. and
  2. Nick Lemoine Ph.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch21

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Fernandez, M. and Lemoine, N. (2002) Tumor/Tissue-Selective Promoters, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch21

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. ICRF Mol Oncology Unit, London, United Kingdom

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • promoter;
  • transcriptional targeting;
  • gene therapy;
  • cancer therapy;
  • transcriptional regulation;
  • enhancer;
  • insulator

Summary

During the last decade gene therapy has emerged as a novel option to conventional chemical and radiotherapy for cancer treatment. As with these therapies, specificity is an important issue that needs to be addressed. With the increase in our knowledge about transcriptional biology, more regulatory elements are available as potential tools to control the expression of therapeutic genes selectively within cancer cells. In this chapter, the latest achievements made in the field of transcriptional targeting using tumor- and tissue-selective promoters are reviewed.