Chapter 21. Tumor/Tissue-Selective Promoters
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
DOI: 10.1002/0471234303.ch21
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Vector Targeting for Therapeutic Gene Delivery
Additional Information
How to Cite
Fernandez, M. and Lemoine, N. (2003) Tumor/Tissue-Selective Promoters, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch21
Editor Information
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
Publication History
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
ISBN Information
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Summary
- Chapter
Keywords:
- promoter;
- transcriptional targeting;
- gene therapy;
- cancer therapy;
- transcriptional regulation;
- enhancer;
- insulator
Summary
During the last decade gene therapy has emerged as a novel option to conventional chemical and radiotherapy for cancer treatment. As with these therapies, specificity is an important issue that needs to be addressed. With the increase in our knowledge about transcriptional biology, more regulatory elements are available as potential tools to control the expression of therapeutic genes selectively within cancer cells. In this chapter, the latest achievements made in the field of transcriptional targeting using tumor- and tissue-selective promoters are reviewed.