Chapter 23. Physiological Targeting

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. Katie Binley Ph.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch23

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Binley, K. (2002) Physiological Targeting, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch23

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. Oxford BioMedica (UK) Ltd, Medawar Centre, Oxford, United Kingdom

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • hypoxia;
  • HIF1;
  • low glucose;
  • heat shock;
  • physiological stress;
  • induction;
  • ischemia

Summary

A number of physiological changes occur in tissue at the onset of disease, for example decreases in oxygen and nutrient availability are common features of ischemic disease and cancer. Cells respond transcriptionally to these physiological changes by up-regulating a set of genes through ubiquitous signalling cascades that promote cell survival. The physiologically responsive promoters that bring about this transcriptional response can be harnessed to provide disease-related control of transgene expression in response to the physiological change.