Chapter 23. Physiological Targeting
- David T. Curiel M.D. and
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Binley, K. (2003) Physiological Targeting, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch23
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- low glucose;
- heat shock;
- physiological stress;
A number of physiological changes occur in tissue at the onset of disease, for example decreases in oxygen and nutrient availability are common features of ischemic disease and cancer. Cells respond transcriptionally to these physiological changes by up-regulating a set of genes through ubiquitous signalling cascades that promote cell survival. The physiologically responsive promoters that bring about this transcriptional response can be harnessed to provide disease-related control of transgene expression in response to the physiological change.