Chapter 7. Genetic Targeting of Adenoviral Vectors
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
DOI: 10.1002/0471234303.ch7
Copyright © 2002 John Wiley & Sons, Inc.
Book Title
Vector Targeting for Therapeutic Gene Delivery
Additional Information
How to Cite
Wickham, T. J. (2003) Genetic Targeting of Adenoviral Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch7
Editor Information
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
Publication History
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
ISBN Information
Print ISBN: 9780471434795
Online ISBN: 9780471234302
- Summary
- Chapter
Keywords:
- adenovirus;
- targeting;
- receptor;
- CAR;
- integrins;
- fiber;
- penton base;
- cancer;
- ligand;
- peptides
Summary
Multiple clinical protocols using adenovirus vectors are currently entering pivotal clinical trials. Despite these successes, the lack of tissue specificity of first generation adenovirus vectors has restricted their use for certain applications. This review will focus on advances and future directions for increasing the efficiency and specificity of adenovectors. Based upon recent advances it is highly likely that truly targeted adenovirus vectors will soon be developed for clinical application. This achievement will open up a whole new era in adenovirus gene therapy where the vector is selectively designed for the disease indication.