Chapter 8. Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification

  1. David T. Curiel M.D. and
  2. Joanne T. Douglas Ph.D.
  1. David T. Curiel M.D.

Published Online: 31 MAR 2003

DOI: 10.1002/0471234303.ch8

Vector Targeting for Therapeutic Gene Delivery

Vector Targeting for Therapeutic Gene Delivery

How to Cite

Curiel, D. T. (2002) Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch8

Editor Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Author Information

  1. Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA

Publication History

  1. Published Online: 31 MAR 2003
  2. Published Print: 9 AUG 2002

ISBN Information

Print ISBN: 9780471434795

Online ISBN: 9780471234302

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Keywords:

  • adenovirus;
  • vector;
  • tropism;
  • fiber;
  • hexon;
  • CAR

Summary

Strategies to alter the tropism of adenovirus provide the means to enhance vector potency and to allow cell-specific targeting. One approach to this end involves genetic capsid modification. Specifically, incorporation of targeting ligands within the capsid structure can allow substantial alterations in tropism. Various capsid sites have been studied as locales for incorporation of heterologous targeting ligands. At present, the ideal site for incorporation of such ligands with fidelity preservation has not been identified. None-the-less, efforts to date have allowed significant gain in terms of the goals of vector potency enhancement and cell specific targeting.