Chapter 8. Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification
- David T. Curiel M.D.,
- Joanne T. Douglas Ph.D.
Published Online: 31 MAR 2003
Copyright © 2002 John Wiley & Sons, Inc.
Vector Targeting for Therapeutic Gene Delivery
How to Cite
Curiel, D. T. (2003) Strategies to Alter the Tropism of Adenoviral Vectors via Genetic Capsid Modification, in Vector Targeting for Therapeutic Gene Delivery (eds D. T. Curiel and J. T. Douglas), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0471234303.ch8
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, The University of Alabama at Birmingham, USA
- Published Online: 31 MAR 2003
- Published Print: 9 AUG 2002
Print ISBN: 9780471434795
Online ISBN: 9780471234302
Strategies to alter the tropism of adenovirus provide the means to enhance vector potency and to allow cell-specific targeting. One approach to this end involves genetic capsid modification. Specifically, incorporation of targeting ligands within the capsid structure can allow substantial alterations in tropism. Various capsid sites have been studied as locales for incorporation of heterologous targeting ligands. At present, the ideal site for incorporation of such ligands with fidelity preservation has not been identified. None-the-less, efforts to date have allowed significant gain in terms of the goals of vector potency enhancement and cell specific targeting.