Standard Article

Expectorants, Antitussives, and Related Agents

  1. David B. Paul,
  2. Robert H. Dobberstein

Published Online: 4 DEC 2000

DOI: 10.1002/0471238961.0524160516012112.a01

Kirk-Othmer Encyclopedia of Chemical Technology

Kirk-Othmer Encyclopedia of Chemical Technology

How to Cite

Paul, D. B. and Dobberstein, R. H. 2000. Expectorants, Antitussives, and Related Agents. Kirk-Othmer Encyclopedia of Chemical Technology. .

Author Information

  1. Sandoz Pharmaceuticals Corp.

Publication History

  1. Published Online: 4 DEC 2000

Chemistry Terms

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Abstract

Expectorants enhance the projection of respiratory tract fluid and thus facilitate the mobilization and discharge of bronchial secretions. Stimulant expectorants increase respiratory tract secretion by a direct effect on the bronchial secretory cells, and sedative expectorants act by gastric reflex stimulation. Classes of expectorants discussed include quaiacols, volatile oils, iodides and other inorganic compounds, and miscellaneous natural products.

Mucolytics reduce the viscosity of tenacious and purulent mucus, thus facilitating removal. Some agents discussed that chemically depolymerize certain components of mucus include trypsin, other proteolytic enzymes, and cis-4-hydroxymethyl-2-iodomethyl-1,3-dioxolane.

Antitussives control excessive coughing. A brief description of the cough reflex is presented. Centrally active antitussives, both narcotic and nonnarcotic, as well as peripherally active antitussives are presented and discussed.

Keywords:

  • Expectorants;
  • Mucolytics;
  • Antitussives;
  • Cough reflex;
  • Guaicol;
  • Volatile oils;
  • Natural products;
  • Nonnarcotic antitussives

Featured Compounds

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  1. 1 - 68
Compound 4
Molecular Weight:198.2158
Molecular Formula:C10H14O4
InChIKey:HSRJKNPTNIJEKV-UHFFFAOYSA-N
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Compound 1
Molecular Weight:124.1372
Molecular Formula:C7H8O2
InChIKey:LHGVFZTZFXWLCP-UHFFFAOYSA-N
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Compound 2
Molecular Weight:138.1638
Molecular Formula:C8H10O2
InChIKey:PETRWTHZSKVLRE-UHFFFAOYSA-N
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Compound 3
Molecular Weight:274.2687
Molecular Formula:C15H14O5
InChIKey:ORUJFMPWKPVXLZ-UHFFFAOYSA-N
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Compound 5
Molecular Weight:286.2794
Molecular Formula:C16H14O5
InChIKey:HSJFYRYGGKLQBT-UHFFFAOYSA-N
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Compound 11
Molecular Weight:152.2334
Molecular Formula:C10H16O
InChIKey:DSSYKIVIOFKYAU-UHFFFAOYSA-N
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Compound 6
Molecular Weight:136.234
Molecular Formula:C10H16
InChIKey:GRWFGVWFFZKLTI-UHFFFAOYSA-N
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Compound 7
Molecular Weight:136.234
Molecular Formula:C10H16
InChIKey:Not Available
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Compound 8
Molecular Weight:148.2017
Molecular Formula:C10H12O
InChIKey:Not Available
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Compound 9
Molecular Weight:154.2493
Molecular Formula:C10H18O
InChIKey:WEEGYLXZBRQIMU-UHFFFAOYSA-N
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Compound 10
Molecular Weight:190.2799
Molecular Formula:C10H22O3
InChIKey:JGKJMBOJWVAMIJ-UHFFFAOYSA-N
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Compound 12
Molecular Weight:156.2652
Molecular Formula:C10H20O
InChIKey:NOOLISFMXDJSKH-UHFFFAOYSA-N
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Compound 13
Molecular Weight:150.2176
Molecular Formula:C10H14O
InChIKey:MGSRCZKZVOBKFT-UHFFFAOYSA-N
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Compound 14
Molecular Weight:258.0542
Molecular Formula:C6H11IO3
InChIKey:LTINPJMVDKPJJI-UHFFFAOYSA-N
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Compound 15
Molecular Weight:692.7903
Molecular Formula:C36H52O13
InChIKey:NXJOCELNFPGKIV-OGMKKTLRSA-N
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Compound 16
Molecular Weight:332.4339
Molecular Formula:C20H28O4
InChIKey:HQLLRHCTVDVUJB-UHFFFAOYSA-N
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Compound 17
Molecular Weight:480.6389
Molecular Formula:C29H40N2O4
InChIKey:AUVVAXYIELKVAI-UHFFFAOYSA-N
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Compound 18
Molecular Weight:466.6123
Molecular Formula:C28H38N2O4
InChIKey:DTGZHCFJNDAHEN-UHFFFAOYSA-N
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Compound 19
Molecular Weight:163.195
Molecular Formula:C5H9NO3S
InChIKey:PWKSKIMOESPYIA-UHFFFAOYSA-N
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Compound 20
Molecular Weight:164.179
Molecular Formula:C2H6NaO3S2
InChIKey:XOGTZOOQQBDUSI-UHFFFAOYSA-M
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Compound 21
Molecular Weight:179.194
Molecular Formula:C5H9NO4S
InChIKey:GBFLZEXEOZUWRN-UHFFFAOYSA-N
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Compound 22
Molecular Weight:376.13
Molecular Formula:C14H20Br2N2
InChIKey:OJGDCBLYJGHCIH-UHFFFAOYSA-N
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Compound 23
Molecular Weight:188.2258
Molecular Formula:C11H12N2O
InChIKey:YIICVSCAKJMMDJ-UHFFFAOYSA-N
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Compound 24
Molecular Weight:378.103
Molecular Formula:C13H18Br2N2O
InChIKey:JBDGDEWWOUBZPM-UHFFFAOYSA-N
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Compound 25
Molecular Weight:244.0276
Molecular Formula:C5H9IO3
InChIKey:NEIPZWZQHXCYDV-UHFFFAOYSA-N
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Compound 26
Molecular Weight:388.481
Molecular Formula:C20H24N2O4S
InChIKey:KSOUSZLJLVVDLQ-UHFFFAOYSA-N
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Compound 27
Molecular Weight:299.3642
Molecular Formula:C18H21NO3
InChIKey:OROGSEYTTFOCAN-UHFFFAOYSA-N
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Compound 28
Molecular Weight:285.3377
Molecular Formula:C17H19NO3
InChIKey:BQJCRHHNABKAKU-UHFFFAOYSA-N
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Compound 29
Molecular Weight:313.3908
Molecular Formula:C19H23NO3
InChIKey:OGDVEMNWJVYAJL-UHFFFAOYSA-N
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Compound 30
Molecular Weight:398.4953
Molecular Formula:C23H30N2O4
InChIKey:GPFAJKDEDBRFOS-UHFFFAOYSA-N
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Compound 31
Molecular Weight:285.3377
Molecular Formula:C17H19NO3
InChIKey:WVLOADHCBXTIJK-UHFFFAOYSA-N
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Compound 32
Molecular Weight:299.3642
Molecular Formula:C18H21NO3
InChIKey:LLPOLZWFYMWNKH-UHFFFAOYSA-N
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Compound 33
Molecular Weight:301.3801
Molecular Formula:C18H23NO3
InChIKey:RBOXVHNMENFORY-UHFFFAOYSA-N
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Compound 34
Molecular Weight:341.4009
Molecular Formula:C20H23NO4
InChIKey:RRJQTGHQFYTZOW-UHFFFAOYSA-N
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Compound 35
Molecular Weight:327.4605
Molecular Formula:C21H29NO2
InChIKey:IFKLAQQSCNILHL-UHFFFAOYSA-N
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Compound 36
Molecular Weight:333.422
Molecular Formula:C19H27NO4
InChIKey:LCAHPIFLPICNRW-UHFFFAOYSA-N
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Compound 37
Molecular Weight:309.4452
Molecular Formula:C21H27NO
InChIKey:USSIQXCVUWKGNF-UHFFFAOYSA-N
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Compound 38
Molecular Weight:247.3327
Molecular Formula:C15H21NO2
InChIKey:XADCESSVHJOZHK-UHFFFAOYSA-N
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Compound 39
Molecular Weight:271.3972
Molecular Formula:C18H25NO
InChIKey:MKXZASYAUGDDCJ-UHFFFAOYSA-N
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Compound 40
Molecular Weight:241.3712
Molecular Formula:C17H23N
InChIKey:IHBSVVZENGBQDY-UHFFFAOYSA-N
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Compound 41
Molecular Weight:255.3978
Molecular Formula:C18H25N
InChIKey:KBEZZLAAKIIPFK-UHFFFAOYSA-N
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Compound 42
Molecular Weight:339.4712
Molecular Formula:C22H29NO2
InChIKey:XLMALTXPSGQGBX-UHFFFAOYSA-N
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Compound 43
Molecular Weight:191.2695
Molecular Formula:C12H17NO
InChIKey:IBKTXALXQACSRE-UHFFFAOYSA-N
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Compound 44
Molecular Weight:283.4079
Molecular Formula:C19H25NO
InChIKey:INTCGJHAECYOBW-UHFFFAOYSA-N
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Compound 45
Molecular Weight:413.4205
Molecular Formula:C22H23NO7
InChIKey:AKNNEGZIBPJZJG-UHFFFAOYSA-N
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Compound 46
Molecular Weight:603.7419
Molecular Formula:C30H53NO11
InChIKey:MAFMQEKGGFWBAB-UHFFFAOYSA-N
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Compound 47
Molecular Weight:358.455
Molecular Formula:C19H22N2O3S
InChIKey:OOVJCSPCMCAXEX-UHFFFAOYSA-N
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Compound 48
Molecular Weight:399.507
Molecular Formula:C21H25N3O3S
InChIKey:DTVJXCOMJLLMAK-UHFFFAOYSA-N
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Compound 49
Molecular Weight:289.8
Molecular Formula:C17H20ClNO
InChIKey:WRCHFMBCVFFYEQ-UHFFFAOYSA-N
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Compound 50
Molecular Weight:244.3752
Molecular Formula:C16H24N2
InChIKey:WFLSCFISQHLEED-UHFFFAOYSA-N
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Compound 51
Molecular Weight:289.4125
Molecular Formula:C18H27NO2
InChIKey:OFAIGZWCDGNZGT-UHFFFAOYSA-N
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Compound 52
Molecular Weight:333.465
Molecular Formula:C20H31NO3
InChIKey:CFJMRBQWBDQYMK-UHFFFAOYSA-N
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Compound 53
Molecular Weight:190.2384
Molecular Formula:C12H14O2
InChIKey:RHPCYZLXNNRRMB-UHFFFAOYSA-N
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Compound 54
Molecular Weight:335.4809
Molecular Formula:C20H33NO3
InChIKey:IQADUMSPOQKAAO-UHFFFAOYSA-N
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Compound 55
Molecular Weight:255.3547
Molecular Formula:C17H21NO
InChIKey:ZZVUWRFHKOJYTH-UHFFFAOYSA-N
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Compound 56
Molecular Weight:295.4219
Molecular Formula:C19H25N3
InChIKey:MVMXJBMAGBRAHD-UHFFFAOYSA-N
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Compound 57
Molecular Weight:245.3202
Molecular Formula:C14H19N3O
InChIKey:IDCHQQSVJAAUQQ-UHFFFAOYSA-N
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Compound 58
Molecular Weight:384.5118
Molecular Formula:C23H32N2O3
InChIKey:VSTNNAYSCJQCQI-UHFFFAOYSA-N
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Compound 59
Molecular Weight:348.5
Molecular Formula:C20H28O3S
InChIKey:ZAMACTJOCIFTPJ-UHFFFAOYSA-N
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Compound 60
Molecular Weight:284.74
Molecular Formula:C16H13ClN2O
InChIKey:Not Available
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Compound 61
Molecular Weight:315.711
Molecular Formula:C15H10ClN3O3
InChIKey:DGBIGWXXNGSACT-UHFFFAOYSA-N
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Compound 62
Molecular Weight:346.3346
Molecular Formula:C17H18N2O6
InChIKey:HYIMSNHJOBLJNT-UHFFFAOYSA-N
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Compound 63
Molecular Weight:454.6016
Molecular Formula:C27H38N2O4
InChIKey:Not Available
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Compound 64
Molecular Weight:404.4948
Molecular Formula:C26H26F2N2
InChIKey:SMANXXCATUTDDT-QPJJXVBHSA-N
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Compound 65
Molecular Weight:355.4275
Molecular Formula:C21H25NO4
InChIKey:RUZIUYOSRDWYQF-HNNXBMFYSA-N
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Compound 66
Molecular Weight:401.887
Molecular Formula:C21H24ClN3O3
InChIKey:KSNNEUZOAFRTDS-UHFFFAOYSA-N
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Compound 67
Molecular Weight:272.2512
Molecular Formula:C12H16O7
InChIKey:BJRNKVDFDLYUGJ-RMPHRYRLSA-N
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Compound 68
Molecular Weight:314.4617
Molecular Formula:C21H30O2
InChIKey:CYQFCXCEBYINGO-UHFFFAOYSA-N
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  1. 1 - 68