Unit

UNIT 1.14 Exploring Phenotypic Data at the Rat Genome Database

  1. Simon N. Twigger,
  2. Jennifer S. Smith,
  3. Angela Zuniga-Meyer,
  4. Susan K. Bromberg

Published Online: 1 JUL 2006

DOI: 10.1002/0471250953.bi0114s14

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

N. Twigger, S., S. Smith, J., Zuniga-Meyer, A. and Bromberg, S. K. 2006. Exploring Phenotypic Data at the Rat Genome Database. Current Protocols in Bioinformatics. 14:1.14:1.14.1–1.14.27.

Author Information

  1. Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin

Publication History

  1. Published Online: 1 JUL 2006
  2. Published Print: JUN 2006

This is not the most recent version of the article. View current version (1 DEC 2012)

Abstract

The laboratory rat, Rattus norvegicus, is an important model of human health and disease, and experimental findings in the rat have direct relevance to human-based research. The Rat Genome Database (RGD, http://rgd.mcw.edu) is a model-organism database that provides access to wide variety of curated rat data such as genes and their homologs, quantitative trait loci, phenotypes, comparative mapping, and genome analysis. We present an overview of the database followed by specific examples that can be used to gain experience in employing RGD to explore the wealth of functional data available for the rat. We show how to make associations with the genome and use comparative tools to link the rat with human and mouse in order to integrate results from these three species of critical biomedical importance.

Keywords:

  • Rat;
  • database;
  • quantitative trait;
  • ontology;
  • comparative genomics;
  • genome sequence