Unit

UNIT 1.16 Using the iHOP Information Resource to Mine the Biomedical Literature on Genes, Proteins, and Chemical Compounds

  1. Robert Hoffmann

Published Online: 1 DEC 2007

DOI: 10.1002/0471250953.bi0116s20

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Hoffmann, R. 2007. Using the iHOP Information Resource to Mine the Biomedical Literature on Genes, Proteins, and Chemical Compounds. Current Protocols in Bioinformatics. 20:1.16:1.16.1–1.16.16.

Author Information

  1. Massachusetts Institute of Technology, Cambridge, Massachusetts

Publication History

  1. Published Online: 1 DEC 2007
  2. Published Print: DEC 2007

Abstract

The iHOP (Information Hyperlinked over Proteins) resource employs sophisticated text-mining methods to assist researchers in their quest for information on specific genes and proteins, their physical interactions and regulatory relationships, their relevance in pathologies, and their interactions with chemical compounds. iHOP parses thousands of PubMed documents every day and collects information specific to thousands of different biological molecules. Rather than providing long lists of entire abstracts upon keyword searches, iHOP selectively retrieves information that is specific to genes and proteins, and summarizes their interactions and functions. In iHOP, with genes and proteins acting as hyperlinks between sentences and abstracts, a large part of the PubMed knowledgebase becomes a giant navigable information network. Curr. Protoc. Bioinform. 20:1.16.1-1.16.16. © 2007 by John Wiley & Sons, Inc.

Keywords:

  • information resource;
  • literature network;
  • PubMed hyperlinked;
  • gene-guided exploration