UNIT 2.1 An Introduction to Recognizing Functional Domains
Published Online: 1 AUG 2002
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Stormo, G. 2002. An Introduction to Recognizing Functional Domains. Current Protocols in Bioinformatics. 2:2.1.
- Published Online: 1 AUG 2002
- Published Print: JAN 2003
This is not the most recent version of the article. View current version (1 JUN 2011)
This unit provides an overview of issues involved in domain recognition in protein and DNA sequences. It opens with a discussion of the two primary methods of domain representation, namely consensus sequences and alignment matrices (e.g., the log-odds matrix). The unit continues with a brief overview of some of the resources available for identifying functional domains in nucleotide sequences (e.g., TRANSFAC, TESS, and MEME). In addition, it reviews databases such as Pfam, and Blocks, which are available for protein analysis.