UNIT 2.1 An Introduction to Recognizing Functional Domains
Published Online: 1 OCT 2006
Copyright © 2006 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Stormo, G. D. 2006. An Introduction to Recognizing Functional Domains. Current Protocols in Bioinformatics. 15:2.1.1–2.1.5.
- Published Online: 1 OCT 2006
- Published Print: SEP 2006
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This unit provides an overview of issues involved in domain recognition in protein and DNA sequences. It opens with a discussion of the two primary methods of domain representation, namely consensus sequences and alignment matrices (e.g., the log-odds matrix). The unit continues with a brief overview of some of the resources available for identifying functional domains in nucleotide sequences (e.g., TRANSFAC). In addition, it reviews databases such as Pfam, InterPro and Blocks, which are available for protein analysis.
- Functional domains;
- protein domains;
- transcription factor binding sites;
- regulatory sites;