UNIT 3.1 An Overview of Sequence Similarity (“Homology”) Searching
Published Online: 1 AUG 2002
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Davison, D. B. 2002. An Overview of Sequence Similarity (“Homology”) Searching. Current Protocols in Bioinformatics. 00:3.1:3.1.1–3.1.7.
- Published Online: 1 AUG 2002
- Published Print: JAN 2003
This is not the most recent version of the article. View current version (1 JUN 2013)
Sequence similarity searching is an essential tool for molecular biologists. It is used to support inference of protein function and for phylogenetic analysis. Every searching procedure requires some understanding of the underlying principles, so at the very least the investigator's selection of parameters is correct. The principles underlying the most commonly used procedures are presented in this unit. The discussion is intentionally non-mathematical, but does contain references for those who desire a mathematical and statistical discussion of these procedures.