UNIT 3.1 An Introduction to Sequence Similarity (“Homology”) Searching
Published Online: 1 JUN 2013
Copyright © 2013 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Pearson, W. R. 2013. An Introduction to Sequence Similarity (“Homology”) Searching. Current Protocols in Bioinformatics. 42:3.1:3.1.1–3.1.8.
- Published Online: 1 JUN 2013
Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequence similarity searches can identify “homologous” proteins or genes by detecting excess similarity— statistically significant similarity that reflects common ancestry. This unit provides an overview of the inference of homology from significant similarity, and introduces other units in this chapter that provide more details on effective strategies for identifying homologs. Curr. Protoc. Bioinform. 42:3.1.1-3.1.8. © 2013 by John Wiley & Sons, Inc.
- sequence similarity;
- sequence alignment;
- multiple alignment;
- sequence evolution