UNIT 3.7 An Overview of Multiple Sequence Alignment
Published Online: 1 NOV 2003
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Simossis, V., Kleinjung, J. and Heringa, J. 2003. An Overview of Multiple Sequence Alignment. Current Protocols in Bioinformatics. 3:3.7:3.7.1–3.7.26.
- Published Online: 1 NOV 2003
- Published Print: SEP 2003
Multiple sequence alignment is perhaps the most commonly applied bioinformatics technique. It often leads to fundamental biological insight into sequence-structure-function relationships of nucleotide or protein sequence families. In this unit, an overview of multiple sequence alignment techniques is presented, covering a history of nearly 30 years from the early pioneering methods to the current state-of-the-art techniques. Methodological and biological issues and end-user considerations, as well as alignment evaluation issues, are discussed.