Unit

UNIT 3.8 Computing Multiple Sequence/Structure Alignments with the T-Coffee Package

  1. Cedric Notredame

Published Online: 1 MAR 2010

DOI: 10.1002/0471250953.bi0308s29

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Notredame, C. 2010. Computing Multiple Sequence/Structure Alignments with the T-Coffee Package. Current Protocols in Bioinformatics. 29:3.8:3.8.1–3.8.25.

Author Information

  1. Centre de Regulació Genòmica, Barcelona, Spain

Publication History

  1. Published Online: 1 MAR 2010
  2. Published Print: MAR 2010

Abstract

In this unit, we describe assembly of a multiple sequence alignment using the T-Coffee package. T-Coffee is much more flexible than most related methods (e.g., ClustalW) because it makes it possible to combine many alternative alignments into a single one, based on an estimate of consistency between these alignments. This strategy can be especially useful when one has to decide among the output produced by several alternative methods. Curr. Protoc. Bioinform. 29:3.8.1-3.8.25. © 2010 by John Wiley & Sons, Inc.

Keywords:

  • sequence alignment;
  • multiple sequence alignment;
  • T-Coffee