UNIT 4.5 Prokaryotic Gene Prediction Using GeneMark and GeneMark.hmm
Published Online: 1 MAY 2003
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Borodovsky, M., Mills, R., Besemer, J. and Lomsadze, A. 2003. Prokaryotic Gene Prediction Using GeneMark and GeneMark.hmm. Current Protocols in Bioinformatics. 1:4.5:4.5.1–4.5.16.
- Published Online: 1 MAY 2003
- Published Print: MAR 2003
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In this unit, the GeneMark and GeneMark.hmm programs are presented as two different methods for the in silico prediction of genes in prokaryotes. GeneMark can be used for whole genome analysis as well as for the local analysis of a particular gene and its surrounding regions. GeneMark.hmm makes use of Hidden Markov models to find the transition points (boundaries) between protein coding states and noncoding states and can be efficiently used for larger genome sequences. These methods can be used in conjunction with each other for a higher sensitivity of gene detection.