UNIT 5.2 FAMS and FAMSBASE for Protein Structure

  1. Hideaki Umeyama,
  2. Mitsuo Iwadate

Published Online: 1 FEB 2004

DOI: 10.1002/0471250953.bi0502s04

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Umeyama, H. and Iwadate, M. 2004. FAMS and FAMSBASE for Protein Structure. Current Protocols in Bioinformatics. 4:5.2:5.2.1–5.2.16.

Author Information

  1. Kitasato University, Tokyo, Japan

Publication History

  1. Published Online: 1 FEB 2004
  2. Published Print: DEC 2003


The computer program FAMS (Full Automatic Modeling System) performs homology modeling of protein structures by means of an algorithm consisting of database searches and simulated annealing. FAMS produces a model in which the torsion angles of the backbone and sidechains are highly accurate. The operations of the FAMS algorithm are fully automated, and, therefore, special knowledge, techniques or experience are not required in order to obtain a biologically worthwhile protein structure.