UNIT 8.7 Using the Reactome Database

  1. Lincoln D. Stein

Published Online: 1 OCT 2004

DOI: 10.1002/0471250953.bi0807s7

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Stein, L. D. 2004. Using the Reactome Database. Current Protocols in Bioinformatics. 7:8.7:8.7.1–8.7.16.

Author Information

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

Publication History

  1. Published Online: 1 OCT 2004
  2. Published Print: SEP 2004

This is not the most recent version of the article. View current version (1 JUN 2012)


There is considerable interest in the bioinformatics community in creating pathway databases. The Reactome project (a collaboration between Cold Spring Harbor Laboratory and the European Bioinformatics Institute) is one such pathway database and collects structured information on all the biological pathways in the human. It is a curated collection of well-documented molecular reactions that span the gamut from simple intermediate metabolism to complex cellular events. This information is supplemented with likely orthologous molecular reactions in mouse, rat, zebrafish, and other model organisms. This unit describes how to use the Reactome database to learn the steps of a biological pathway and see how one pathway interacts with another; navigate and browse through the Reactome database; identify the pathways in which a molecule of interest is involved; use the Pathfinder tool to search the database for possible connections within and between pathways.


  • Reactome;
  • pathway;
  • database;
  • biological pathway