UNIT 8.7 Using the Reactome Database
Published Online: 1 OCT 2004
Copyright © 2004 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Bioinformatics
How to Cite
Stein, L. D. 2004. Using the Reactome Database. Current Protocols in Bioinformatics. 7:8.7:8.7.1–8.7.16.
- Published Online: 1 OCT 2004
- Published Print: SEP 2004
This is not the most recent version of the article. View current version (1 JUN 2012)
There is considerable interest in the bioinformatics community in creating pathway databases. The Reactome project (a collaboration between Cold Spring Harbor Laboratory and the European Bioinformatics Institute) is one such pathway database and collects structured information on all the biological pathways in the human. It is a curated collection of well-documented molecular reactions that span the gamut from simple intermediate metabolism to complex cellular events. This information is supplemented with likely orthologous molecular reactions in mouse, rat, zebrafish, and other model organisms. This unit describes how to use the Reactome database to learn the steps of a biological pathway and see how one pathway interacts with another; navigate and browse through the Reactome database; identify the pathways in which a molecule of interest is involved; use the Pathfinder tool to search the database for possible connections within and between pathways.
- biological pathway