UNIT 10.1 Introduction to Comparing Large Sequence Sets

  1. Roderic D.M. Page

Published Online: 1 FEB 2003

DOI: 10.1002/0471250953.bi1001s00

Current Protocols in Bioinformatics

Current Protocols in Bioinformatics

How to Cite

Page, R. D. 2003. Introduction to Comparing Large Sequence Sets. Current Protocols in Bioinformatics. 00:10.1:10.1.1–10.1.2.

Author Information

  1. University of Glasgow, Glasgow, Scotland

Publication History

  1. Published Online: 1 FEB 2003
  2. Published Print: JAN 2003


Comparisons of whole genomes can yield important insights into the evolution of genome structure, such as the role of inversions in bacterial evolution and the identification of large-scale duplications in the human genome. This unit briefly compares two tools for aligning whole genome sequences: MUMmer and PipMaker. These tools differ in both the underlying algorithms used, and in the interface they present to the user.